Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma
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چکیده
منابع مشابه
Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma.
Recent published reports on clinical trials of CPT-11 indicate the effectiveness of this compound, a prodrug of SN-38, against malignant glioma in combination with anti-vascular endothelial growth factor antibody. Here, we determined if NK012, and SN-38 incorporating micelle, can be an appropriate formulation for glioblastoma treatment compared with CPT-11. In vitro cytotoxicity was evaluated a...
متن کاملNovel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression.
It has been recently reported that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nanodevice, markedly enhances the antitumor activity of SN-38, especially in hypervascular tumors through the enhanced permeability and retention effect. Renal cell carcinoma (RCC) is a typical hypervascular tumor with an irregular vascular architecture. We therefore investigated the antitumor activity...
متن کاملailed Distribution of NK012, an SN-38–Incorporating elle, in the Liver and Its Potent Antitumor Effects
nloaded pose: To clarify and compare the antitumor effects and specific biodistribution of NK012, an –incorporating polymeric micelle, in mice bearing multiple liver metastases of human colon cancer cells with irinotecan hydrochloride (CPT-11). erimental Design: The maximum tolerable dose of NK012 (30 mg/kg) or CPT-11 (66.7 mg/kg) v. administered three times every 4 days to mice bearing metasta...
متن کاملNovel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.
7-Ethyl-10-hydroxy-camptothecin (SN-38), a biological active metabolite of irinotecan hydrochloride (CPT-11), has potent antitumor activity but has not been used clinically because it is a water-insoluble drug. For delivery by i.v. injection, we have successfully developed NK012, a SN-38-releasing nanodevice. The purpose of this study is to investigate the pharmacologic character of NK012 as an...
متن کاملEnhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor.
Human pancreatic cancer is generally hypovascular in nature and rich in interstitium. These pathological barriers may contribute to the intractable nature of pancreatic cancer by binding the penetration of anticancer agents throughout the tumor tissue. The aim of the present study was to determine whether NK012 is an appropriate formulation for the treatment of hypovascular tumors. Among pancre...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2008
ISSN: 0020-7136
DOI: 10.1002/ijc.24171